产品货号：
Z25445
中文名称：
RNF168抗体
英文名称：
Anti-RNF168 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RNF168 Antibody |
| 指标别名 | ring finger protein 168;RNF168 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB |
| 基因名称 | RNF168 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | RNF168 antibody was raised against an 18 amino acid synthetic peptide from near the carboxy terminus of human RNF168.The immunogen is located within amino acids 440 - 490 of RNF168. |
| 计算分子量 | 65kDa |
| 成分 | RNF168 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | RNF168 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo.RNF168 targets histones H2A and H2AX,but not H2B,forming K63 polyubiquitin chains.Upon formation of DNA double strand breaks,RNF168 is recruited to the site of DNA damage where it co-localizes with gammaH2AX and 53BP1 in an RNF8-dependent manner.This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1,facilitating the downstream signaling cascade.Thus,RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintenance.At least three isoforms of RNF168 are known to exist. |
| Uniprot ID | Q8IYW5 |
| 基因名全称 | Ring finger protein 168 |
| 蛋白名全称 | Ring finger protein 168 |
| 推荐稀释比 | RNF168 antibody can be used for detection of RNF168 by Western blot at 1μg/mL.Antibody validated:Western Blot in human samples.All other applications and species not yet tested. |
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